Boston Illegal #19

Thursday evening May 14, 2020 was my 56th official day at home (Shelter in Place).  I have literally not left the house more than 4 times in my car  (Ellen & Susan have been my concierge for food and sundries).  I have physically seen only twelve people for these 56 days.   Since Ohio was opening up it was time for a socially physical distancing time - Boston Legal. #19.

Once the spouses heard about this they decided to have their Boston Illegal on the front patio.  The need for physical social interaction is clearly a mandatory emotional need.  The movie Castaway with Tom Hanks remains one of my favorite movies as it shows the willingness to risk death for relationship connectiveness.

It does not surprise me that the USA is opening up and emotions are riding high between the extroverts and introverts. Suddenly a new education about natural rights and freedoms become the day to day discussions about the shelter-in-place orders and pending orders about masks and gloves.

J.P. had sent me a link to Randy Barnett's discussion about Individual Liberty in a Pandemic.  Little did I understand the overriding weight of my freedom as defined by the Ohio Constitution (vs the Federal Constitution).  I have never read the Ohio Constitution!

No movie for this Boston Legal  -  however I decided to post facto watch one as the suggested homework -   Charlton Heston in "The Omega Man" (1971).   Little did I realize this was just a COVID-19 movie showing all the people that decided to ignore shelter in place and stay out late at night :)

Blame Game - 2

I've caught the "bug" in learning about the mystery of  influenza. Funny how subjects I hated in high school - biology and history - I am now enjoying learning about.   Over the past few days I have watched the Great Courses Lectures #11-13  "The 1918 Flu" - Professor Bruce E. Fleury ;  the Smithsonian America's Hidden Stories - "Pandemic 1918" ;  and the most interesting - a 2014 lecture at the University of Arizona  -  "The Genesis of the 1918 Spanish Influenza Pandemic" ;

Professor Michael Worobey speculates (with very persuasive data) that we can blame the Spanish Flu on a Canadian Horse!   Even more interesting is the history of influenza and what age group may have the best immunity to different strains.

I was most intrigued at Professor Michael Worobey's  answer to the question about this slide stating a "Lab Escape" of H1N1: 

"In 1957 the Spanish Flu went extinct when H2N2 emerged in 1963.  H3N2 kicked out H2N2 but in 1977 there was a kind of mini pandemic and H1N1 re-emerged and bottom line if you look at the molecular clock it [H1N1] was frozen in time not even since 1957 but it was a 1950 N1 strain and it is virtually certain it was an accidental mistake probably from an experimental strain from China or Russia.  And so - yes - the first pathogen in human history was accidentally re-released and not to many people know about it until you guys."

The strange spike in 2017-2018 in deaths from influenza is put in context in this interview with Worobey in Feb. 2018:  

Even Worobey's research on HIV-1 is fascinating discovering strains of this circulating in the 1970's before the outbreak in the US was recognized - see article "Findings of how AIDs spread across North America" 

Bottom-line -  when you were born and what your first battle with influenza was may determine your success in the fight with COVID-19. 

Blame Game

Now the escalating viral gossip circulating the internet and news media is the attempt to find the "cause" of the COVID-19 crisis. The blame game is a natural human tendency - especially when it comes to a virus.   So often when we get the flu we try to determine the cause - or really who gave it to you.  In fact the whole discussion and ramp up for tracing mechanisms is one of the critical needs for relaxing the shelter-in-place to properly quarantine those individuals at risk of spreading the virus.

Tracing automatically reinforces the historical look back at who or where was the first incident.  It was fascinating to listen to the lineage of the Santa Clara County Tracing: 

The conspiracy theories about the source of the virus in Wuhan China and whether it was caused by a mistake in the lab or in the wet market will rage on.  Blaming the Chinese for this virus would be like blaming the USA (now thinking the Spanish Flu started in Kansas) for the start and spread of the Spanish Flu.   What gain comes from blaming anyone for the crisis?

Yes there is always a benefit to understanding a cause if it provides a benefit of avoid future problems.  However when the search for a cause is primarily to "damn" the source and to redirect the attention away from solving the problem while at the same time washing your hands from responsibility of current actions - then looking for the cause is a waste of precious time and resources that can be applied to solving the problem.

Does naming "Patient ZERO" help?  Should we damn that person?  Should we damn wet markets?  Should we damn the Chinese? 

"He who is without sin, cast the first stone"

Normal Numbers Nonsense?

The discussion (sometimes called argument) continues about whether COVID-19 is anymore serious that the normal flu.  Everyone is second guessing each state's Governor's response, the Federal Government's response and comparing our death rate to other countries responses to this pandemic.  J.P. even asked what level of deaths in the U.S. would justify praise for the state and federal response?

The real underlying issue is what is a pandemic?   History provides some clue to this answer.  Start with what is considered the 5-6 Worst Pandemics in History .

(1) The Bubonic Plague/Black Death 1347- 1351 75-200 million deaths worldwide
(2) Spanish Flu (H1N1) -  1918-1919 50 million worldwide deaths (675,000 USA)
(3) Asian Flu  (H2N2) - 1957  1.1 million worldwide deaths (116,000 USA)
(4) Hong Kong Flu (H3N2) - 1968  1 million worldwide deaths (100,000 USA)
(5) Swine Flu (H1N1) - 2009-2010  575,400 worldwide deaths (12,469 USA)
(6) HIV/AIDS -  1980 - 2006  25 million deaths worldwide (still in process)

The Worldometer Coronavirus daily count is now at 233,686 worldwide deaths and 63,765 in USA so by the numbers it may surpass the #4 and #3 in absolute numbers. 

But the absolute numbers are still flawed in revealing a solution.   For example:  The Spanish Flu, which lasted 36 months, in it's first wave (Jan 1918 - October 1918)  killed 200,000 people in the USA (about 0.194% of the 103 million population). The estimated infected population was 1/3 so the actual mortality rate for the first wave was about 0.582%.   Presented in a percentage that number seems no different from the seasonal flu.  This numbers nonsense is used to criticize the shelter-in-place actions (either soft or hard).

A recent RedState article was sent to me "If Wuhan Virus Is SoBad, Why Are Deaths So Low?" that attempted to justify why "There is really no medical reason to pursue this nonsense." The data looks legitimate sourcing from the CDC, yet a quick check on the actual site of Vital Statistics shows quite a different picture.

https://www.cdc.gov/nchs/nvss/vsrr/COVID19/

After lengthy conversation with P.N.,  I gave up trying to use numbers to convince him that this crisis is approaching the severity of the Spanish Flu and is well beyond the mortality numbers of a normal flu season in the USA.  Finally we both agreed that based on today's nonsensical numbers that by year end deaths in the USA could approach 100K - 120K.

It just shows that normal - is in whatever numbers make you feel normal.  And that's the definition of  nonsense - predicting deaths that we call "normal levels".

Lessons of History

"Those who cannot learn from History are doomed to repeat it"  was stated by George Santayana and ironically lived during the Spanish Flu and was from Spain (the country that inherited the name for the tragic Spanish Flu that likely started in Kansas).

I think the country (and possibly the world) might be experiencing deja vu on this COVID-19 pandemic.   Read some of the quotes from the Smithsonian article about the Spanish Flu:

By July [1918] it didn’t seem to matter. As a U.S. Army medical bulletin reported from France, the “epidemic is about at an end...and has been throughout of a benign type.” A British medical journal stated flatly that influenza “has completely disappeared.”

SEPT 1918 The second wave had begun. -  Across the country, public officials were lying. U.S. Surgeon General Rupert Blue said, “There is no cause for alarm if precautions are observed.” New York City’s public health director declared “other bronchial diseases and not the so-called Spanish influenza...[caused] the illness of the majority of persons who were reported ill with influenza.” The Los Angeles public health chief said, “If ordinary precautions are observed there is no cause for alarm.” Now the head of the Army’s communicable disease division, he jotted down his private fear: “If the epidemic continues its mathematical rate of acceleration, civilization could easily disappear...from the face of the earth within a matter of a few more weeks.”  Then, as suddenly as it came, influenza seemed to disappear. It had burned through the available fuel in a given community. An undercurrent of unease remained, but aided by the euphoria accompanying the end of the war, traffic returned to streets, schools and businesses reopened, society returned to normal.

A third wave followed in January 1919, ending in the spring. This was lethal by any standard except the second wave ……   After that third wave, the 1918 virus did not go away, but it did lose its extraordinary lethality, partly because many human immune systems now recognized it and partly because it lost the ability to easily invade the lungs. No longer a bloodthirsty murderer, it evolved into a seasonal influenza.  Another question concerns who died. Even though the death toll was historic, most people who were infected by the pandemic virus survived; in the developed world, the overall mortality was about 2 percent. 

Source:  https://www.smithsonianmag.com/history/journal-plague-year-180965222/

Looking further into the politics of the time, the political fight over entry into WW I preceded the virus and I'm sure Woodrow Wilson became distained for his actions at that time (both War and Pandemic).   

J.P. wondered what level of deaths in the US would justify praise for the state and federal response?  Until the election is over, and we are out of economic hardship, the cacophony of BOTH praise and criticism will be deafening.  Once that time fades in our memory, it will be sounds of silence with another lesson of history forgotten for a more enlightened generation to ignore.  

Jesus Christ could have come down and halted the virus on Easter and there would still be critics saying he arrived on the scene late :)

Virtual Castaway

At 3pm yesterday my mental alarm clock and calendar went off.  I had totally "spaced out" a Zoom meeting that I was to lead at 7pm.   The Shelter in Place has put my life and routine in the Twilight Zone.  I can even remember how many days I have been isolated as a castaway.  Like a prisoner, maybe I should start a daily hash mark on the wall. I started distancing in my office March 9 but transferred to home shelter in place March 24 and haven't been outside my neighborhood more than three times. 

The debate continues about death rates, proper ways to resume business, who's to blame, immediate health risks, and the extent of long term emotional, physical and financial damage. Pressure is building on all fronts.

Call it a "sick" bet but I finally bet a lunch with P.N. on the mortality percentage of estimated COVID-19 infections on November 4th (the day of elections).  This crisis has put a great emphasis on death - an inevitable result for all of us.  Naturally the human instinct is to extend life as long as feasible, and our compassion is demonstrated in our attempts to curtail premature death in others. 

Of the 57million deaths worldwide 54% can be attributed to the top 10 causes: 

Based on this chart - 3 million are lower respiratory infections (Influenza; pneumonia).   Also this chart varies dramatically based on developed countries and undeveloped countries.

The macro view of humanity is to understand how to allocate economic resources to slow the rate of death for the greatest number of individuals (a utilitarian philosophy).   However, the individual personal decision comes down to the selfish motive of extending your life with family and friends.  

The tragedy of this crisis is the inability to be near those you love who are dying. No one wants to die alone!   As virtual castaways, how can we be near those we love who are dying?  -  only one way.  The same way to extend life beyond this world.

Micro vs Macro Views

Some might title the micro view of this crisis "Looking out for #1" ( like the 70's book by Robert Ringer) - it all comes down to "How will the COVID-19 affect me and my family?

For two weeks I've been looking through the rear view mirror at COVID-19 data (Worldwide, USA and State). Even trying to forecast the traffic pattern and peak rush hour risk in the future (with limited success).  But how do you predict what's happening on the local road you are traveling on?  How can you predict how many cars are on YOUR local road and how many are on the road miles ahead of your present position?   More cars are entering the road hourly, more probability of collision with the chance of major accident with possible fatal outcomes.

That took me to the Seattle and King County road map.  Why not see what happened there where the first car entered the USA highway network.

I was amazed at the quality of the Seattle and King County Public Health site and Coronavirus Dashboard:

As a Statistician, I know it is dangerous to pick one data point especially since at least 55 of the cases and 20 of the deaths in King County are related to one physical site - Life Care Center of Kirkland.  This instance makes up almost 10% of the County Deaths all of which were probably residents over the age of 80.   But even with that outlier this data is worth reviewing.

Here are my observations  (rounded for convenience):
(1)  87% of those tested  are Negative
(2) Number of tests per day is about 1K
(3) While the compounded growth rate since the first instance (2/28) to April 4 is 29%, the daily percentage increase was about 4% for April 4th.
(4) More Men than Women test Positive  (W-11%;  M-16%)
(5)You don't want to be 80+ in age (Death % of Positive Cases = 24%)
(7) Best to be under 60  0.8% (Death % of Positive Cases)
(8) Better to be female that male (W-8% Death; M-6% Death)

When looking at the micro view - the fear depends on your age and sex (also pre-existing health issues as reported elsewhere). Now suddenly the potential solutions become more individualized.

The micro view would focus on individual quarantine and age and health based physical/social distancing or shelter-in-place.  This might be a ramp-up strategy for restarting the US economy.

Whether micro of macro, the actions to take will be an experiment we will all have to live with and learn from for future outbreaks.